Oral antibiotics may replace surgery for uncomplicated appendicitis.
A clinical trial is set to evaluate the efficacy of oral moxifloxacin versus placebo in treating uncomplicated acute appendicitis without hospitalization. Targeting adults aged 18-60, the APPAC IV trial will assess treatment success 30 days post-discharge, aiming to determine if antibiotics and inpatient care can be safely eliminated. This noninferiority trial, conducted across nine Finnish hospitals, seeks to address a significant gap in managing appendicitis with antibiotic therapy alone.
Patients who needed emergency general surgery within 60 days of a pulmonary embolism had more major complications than those operated on later, in a national database study.
Among 3,785 patients who had emergency general surgery after acute pulmonary embolism, those operated on at least 60 days later had markedly fewer major adverse events (adjusted OR 0.45, 95% CI 0.37–0.55).
Appendix, Gallbladder and Surgical Emergencies3 Nov 2026
