New guidelines offer personalized strategies for rectal adenocarcinoma

French intergroup clinical practice guidelines for managing rectal adenocarcinoma were published in September 2023. The guidelines categorize treatment based on tumor stage, with specific recommendations for endoscopic and surgical excision, radical surgery, and total neoadjuvant treatment. Additionally, they emphasize rectal conservation for select small tumors responding well to previous therapies. Immunotherapy is highlighted for certain cases, while the approach for metastatic tumors remains informed by less robust evidence. Multidisciplinary consultation is essential for optimal care.