Preoperative tumor markers predict surgical outcomes in peritoneal metastases

Clustering preoperative tumor marker patterns aids in predicting surgical outcomes for patients with peritoneal metastases. Among 138 with pseudomyxoma peritonei (pMP), two distinct clusters emerged—pMP cluster-1 had a 5-year overall survival rate of 77%, while pMP cluster-2 faced a significantly poorer prognosis of 36%. A similar pattern was observed in 213 colorectal peritoneal metastases patients, with colorectal cluster-1 showing a 28% survival rate. Elevated markers indicated higher open-close surgery risks.