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Intestine and Lower Gastrointestinal Tract ·

Circulating tumor DNA strongly predicts recurrence risk in colorectal cancer.

A tumor-informed circulating tumor DNA (ctDNA) assay was found to be highly prognostic for recurrence risk in stage III colorectal cancer patients. Among 124 patients analyzed over a median follow-up of 4.8 years, ctDNA status exhibited a significant association with recurrence-free survival. The estimated 3-year recurrence-free survival rates were markedly different between ctDNA positive (54.5% after surgery, 18.2% after therapy) and negative patients (96.1% and 90.0%, respectively), emphasizing its predictive value.

Journal Article by Diergaarde B, Young G (…) Schoen RE et 7 al. in J Surg Oncol

Journal of Surgical Oncology© 2024 Exact Sciences Corporation and The Author(s). Journal of Surgical Oncology published by Wiley Periodicals LLC.

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