Intraoperative blood loss impacts morbidity after liver surgery

Among 2,491 patients undergoing liver cancer surgery, significant associations were found between adjusted blood loss (ABL) and postoperative complications. Patients with ABL below 8.5 ml/kg experienced a lower comprehensive complication index (CCI) of 10.6 compared to 15.2 in those with higher ABL (p < 0.001). A nonlinear correlation indicated CCI increases sharply beyond 10 ml/kg, and survival rates worsened with ABL ≥ 8.5 ml/kg, suggesting the importance of limiting blood loss during liver resections to enhance patient outcomes.