Molecular Differences in Pancreatic Cancer Highlight Racial Disparities

Racial disparities in pancreatic cancer survival are linked to distinct immune microenvironments and genomic profiles. In a comprehensive analysis of 4,679 pancreatic adenocarcinoma samples, African American patients exhibited a higher frequency of TP53 mutations than European Americans. Additionally, gene expression profiling indicated significant immunologic differences between the two groups. These findings suggest that understanding these molecular variations is vital for improving treatment and outcomes, particularly for African American patients facing worse prognoses.