Mortality from necrotizing fasciitis sharply increases in the U.S.

Between 2003 and 2020, necrotizing fasciitis (NF) deaths in the U.S. surged by 120.6%, from 824 to 1,842 annually. The age-adjusted mortality rate rose from 0.44 to 0.71 per 100,000 people. Males faced higher mortality overall, with a stark rise post-2015. American Indian or Alaska Native groups reported the highest rates, while regional disparities were evident, with the West experiencing the most deaths. Public health efforts are necessary to address healthcare inequities and improve outcomes.