Adverse events during colorectal ESD increase with age.

A nationwide study in Japan reveals that the risk of adverse events (AEs) during colorectal endoscopic submucosal dissection (ESD) escalates significantly in older adults, particularly those aged 85 and above. Among 143,925 patients, AEs were recorded at 5.3% for ages 60-64, rising to 9.2% for those over 90. The analysis highlighted significant post-operative bleeding as the predominant complication, with anticoagulant use and high body mass index (≥30) identified as critical risk factors.