Analysis of data from over 28,000 trauma patients reveals that tranexamic acid significantly reduces 24-hour mortality, particularly when administered within 2 hours of injury. The effectiveness diminishes quickly after this window. While benefits may extend beyond 2 hours for patients with severe traumatic brain injuries, the strongest results were noted in individuals with low blood pressure and low Glasgow Coma Scale scores. Optimal treatment criteria were established for timely administration.
Randomized Controlled Trial by Osawa I, Goto T and Roberts I in Br J Surg
© The Author(s) 2025. Published by Oxford University Press on behalf of BJS Foundation Ltd. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.