Serum EV-MDM2 Levels May Indicate Liposarcoma Recurrence

Elevated levels of extracellular vesicle (EV) MDM2-DNA in retroperitoneal liposarcoma patients suggest this biomarker could identify disease recurrence. In a study involving 42 patients, EV-MDM2 levels were significantly higher in individuals with well-differentiated or dedifferentiated liposarcoma compared to healthy controls. Post-surgery, levels dropped but rose again during follow-up for some, aligning with imaging evidence of disease recurrence. These findings indicate EV-MDM2’s potential in guiding early surveillance and treatment decisions for liposarcoma.