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CPZ demonstrates high sensitivity for diagnosing hepatocellular carcinoma

Carboxypeptidase Z (CPZ) emerges as a promising diagnostic biomarker for hepatocellular carcinoma (HCC), showing a remarkable 90.8% positive expression rate in a study of tumor tissues. In combination with other markers, CPZ achieved sensitivities up to 79.2% and specificities near 100%. Notably, it outperformed other markers in poorly differentiated HCC, suggesting its potential role in routine pathology. High accuracy was highlighted with an AUC of 0.908 for CPZ alone, underscoring its diagnostic value.

Journal Article by Deng M, Luo R (…) Hou Y et 8 al. in Am J Surg Pathol

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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