A novel drug-eluting, biologically absorbable suture from decellularized fish swim bladder significantly enhances wound closure across various tissues. Specifically, necrostatin-1 (nec-1) sutures exhibit superior tensile strength and maintain integrity in extreme pH conditions. The drug-loaded sutures inhibit cell proliferation by 40% and reduce foreign body reactions, with less neovascularization observed compared to controls. These findings suggest that swim bladder-derived sutures can improve surgical outcomes by minimizing inflammation and offering staged drug release.
Journal Article by Sun P, Cui H (…) Lai Y et 3 al. in Int J Surg
Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.