Findings indicate that increased calprotectin levels in drain fluid post colorectal surgery serve as reliable predictors of early anastomotic leakage (AL). In a cohort of 306 patients, those developing AL exhibited significantly higher calprotectin levels starting from the third postoperative day. Specifically, levels exceeding 110 ng/ml demonstrated 92% sensitivity and 82% specificity for detecting preclinical AL. This marker may enhance early postoperative management, outperforming traditional inflammatory indicators like C-reactive protein and interleukin-6.
Journal Article by Ling L, Zuo Z (…) Zheng W et 6 al. in World J Surg Oncol
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