A single GNAS droplet digital PCR (ddPCR) analysis improves the diagnostic accuracy for mucinous pancreatic cystic lesions (MPCNs) using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Among 140 patients, ddPCR increased MPCN detection to 62% while yielding 100% specificity. The method also identified a third of inconclusive lesions as MPCNs. Importantly, GNAS-ddPCR demonstrated a 24% cost reduction compared to next-generation sequencing, offering a simple means to enhance diagnostic capabilities for pancreatic cysts.
Journal Article by Ik A, G S (…) Ec V et 13 al. in Clin Transl Gastroenterol
Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.