Postcolonoscopy colorectal cancers show distinct serrated characteristics

A systematic review of 15 studies reveals postcolonoscopy colorectal cancers (PCCRCs) have notable molecular differences from sporadic colorectal cancers (SCRCs). PCCRCs are more often linked to the serrated pathway, showing higher rates of microsatellite instability (MSI), CPG island methylator phenotype (CIMP), and BRAF mutations, while exhibiting less frequent KRAS mutations. Although their five-year survival rate is similar to SCRC, PCCRCs fare worse compared to screening-detected cases. Enhancing serrated lesion detection can significantly boost screening efficacy.