Appendicitis-related mortality trends reveal concerning gender disparities

From 1999 to 2020, appendicitis-related mortality decreased overall but revealed significant disparities. The age-adjusted mortality rate fell from 0.38 to 0.32 per 100,000, with a notable decline for males but a concerning rise for females since 2016. Black individuals had the highest mortality rates, although significant declines were observed across racial groups. Nonmetropolitan regions experienced higher mortality rates than metropolitan areas, emphasizing the need for focused interventions to improve access to surgical care and address these disparities.