A seven-gene prognostic model derived from the ATF/CREB family effectively stratifies adrenocortical carcinoma (ACC) patients into high- and low-risk groups based on overall survival. This model not only serves as an independent prognostic factor across various clinical settings but also reveals unique immune characteristics linked to high-risk patients, including reduced CD8+ T cell presence and immune checkpoint expression. Experimental findings confirm ATF4’s role in promoting ACC cell proliferation.
Journal Article by Wu K, Jia Y (…) Liu Z et 6 al. in Int J Surg
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