Enzymatic interactions from pancreatic juice cause critical vascular damage post-surgery, leading to severe hemorrhage. A study on porcine models reveals that trypsin and chymotrypsin significantly weaken arterial walls when mixed with intestinal fluids. However, administering nafamostat mesylate, a protease inhibitor, effectively mitigates this histopathologic damage. This finding underscores the potential for localized delivery of inhibitors around vascular stumps to reduce life-threatening complications following pancreatoduodenectomy.
Journal Article by Seki Y, Ishizawa T (…) Hasegawa K et 9 al. in BMC Surg
Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.