A novel perineural invasion (PNI) severity score effectively predicts disease recurrence and survival in resected pancreatic ductal adenocarcinoma. Among 300 patients, PNI severity correlated with worse pathological outcomes: shorter recurrence times (24 months for PNI 0 vs. 15 months for PNI 2) and reduced survival (57 months for PNI 0 vs. 32 months for PNI 2). PNI 2 patients particularly benefited from adjuvant treatment, achieving longer recurrence-free and overall survival rates.
Journal Article by Gasparini G, Crippa S (…) Falconi M et 12 al. in Ann Surg
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