A two-week hypofractionated chemoradiotherapy regimen yielded similar tumor responses to conventional long-course treatment in locally advanced rectal cancer. Analyses showed comparable rates of downstaging and tumor response between the two approaches. Notably, the two-week regimen significantly reduced gastrointestinal toxicity, with only 5.8% experiencing grade 2 or higher complications versus 13.2% in the standard group. This trial supports shorter treatment durations without sacrificing efficacy.
Journal Article by Choi KH, Kim SH (…) An C et 9 al. in Ann Surg
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