Intestine and Lower Gastrointestinal Tract · 24 September 2025

Achieving YpN0 Status Significantly Enhances Survival in Rectal Cancer

Patients with locally advanced rectal cancer who achieve YpN0 status after neoadjuvant therapy show promising survival rates. In a cohort from the FOWARC trial, five-year overall survival reached 88% for natural N0 and 89% for downstaged N0, far surpassing the 73% survival in YpN+ patients (p=0.0034). This underscores YpN0’s role as an independent prognostic factor, guiding tailored postoperative strategies for improved outcomes.

Journal Article by Wan H, Weng J (…) Luo Y et 16 al. in Dis Colon Rectum

read the whole article in Dis Colon Rectum

open it in PubMed

Summaries are written to help you decide what to read. They do not replace the full paper.

Free · 5 minutes a day

Get every new paper in Intestine and Lower Gastrointestinal Tract.

Plus the Daily Selection: the five most relevant papers of the day, each cut to its key points.

More in Intestine and Lower Gastrointestinal Tract

The latest stitches

Ann Surg Oncol2 Nov 2026

Smoking linked to weaker rectal cancer response

Patients smoking at diagnosis were less likely to have a favorable response to treatment before rectal cancer surgery; former smokers were not.

JAMA Surg30 Oct 2026

Subtotal colectomy matches total for constipation

For severe slow-transit constipation, removing less colon gave similar symptom relief at one year, with less early incontinence.

Surg Endosc29 Oct 2026

Fewer wound problems linked to transanal extraction

In low rectal cancer surgery, removing the specimen through the anus was linked to fewer wound complications and less pain in the first two days.

All papers in Intestine and Lower Gastrointestinal Tract →