Methylene blue effectively alleviates postoperative pain and decreases analgesic use in hemorrhoid surgery patients. A meta-analysis of six studies with 598 participants revealed significant pain reduction within 12 hours post-surgery, along with lower analgesic requirements. Importantly, methylene blue demonstrated a safety profile without increasing complications. These results underscore the potential of methylene blue as a key adjunct in managing postoperative pain, prompting a call for detailed usage guidelines and specialized formulations for colorectal treatments.
Journal Article by Zhu YJ, Shi YT, Shi SY and Xu L in Ann Med