Enhancing the fibrinogen-to-erythrocyte suspension ratio could significantly reduce mortality and improve functional outcomes in major perioperative bleeding scenarios. The ADEFES study focuses on patients undergoing surgeries that entail substantial blood loss, evaluating the relationship between fibrinogen supplementation and critical recovery metrics. By scrutinizing the effect on both all-cause and bleeding-specific mortality alongside daily living scores, this multicenter observational study aims to fill a crucial gap in clinical guidance for blood product replacement during surgery.
Multicenter Study by Demir ZA, Kavak Akelma F (…) Aydın Güzey N et 10 al. in BMJ Open
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