Surgical resection significantly improves survival for hepatocellular carcinoma patients who reach complete response following triple therapy.

• One-, two-, and three-year survival rates post-surgery were 96.0%, 90.8%, and 90.8%, compared to 91.3%, 85.8%, and 73.1% for nonsurgical management.
• Patients who underwent surgery saw 70.9% achieve pathological complete response; however, the overall complication rate was 24.2%.

Surgical resection should be strongly considered for these patients to enhance outcomes.