Surgeons can now identify non-functioning pancreatic neuroendocrine tumors at high risk for early recurrence preoperatively.

• Early recurrence occurred in 11% of patients, with a median disease-free survival of 16 months.
• Neoplastic venous thrombosis predicted a 71% chance of early recurrence; without it, patients with a KI-67 index ≥5% and tumor size ≥3 cm had a 19-41% recurrence risk.

Incorporating this model can enhance surgical decision-making and patient counseling regarding prognosis.