HPB & Spleen · 31 October 2025

Revolutionary Prognostic Tool for Intrahepatic Cholangiocarcinoma

A novel grading system combining CA19-9, CA125, and CEA significantly improves prognostic accuracy for intrahepatic cholangiocarcinoma patients post-surgery.

In a study of 535 patients, the combined 3c grade correlated with overall survival and recurrence-free survival, outperforming individual markers (p < 0.001).
Tumor size and lymph node metastasis distinguished between 3c grade groups (p = 0.006).

This model offers surgeons critical insights for preoperative risk assessment and tailored treatment strategies for IC patients.

Journal Article by Wang T and Liu J in Ann Surg Treat Res

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