This study evaluates real-world outcomes of various inguinal hernia mesh products to identify safety alerts for reoperation rates.

• None of the top three most-used open mesh products (Progrip, Parietex, Perfix) triggered alerts, with reoperation rates below 2%.
• Surgipro and Kugel demonstrated concerning reoperation rates of 1.7% and 2.5%, respectively, triggering safety alerts.
• Among minimally invasive meshes, Parietex had a reoperation rate of 2.1%, exceeding safe limits.

Surgeons should weigh mesh selection carefully based on these findings to optimize patient outcomes.