Higher lifestyle health scores may reduce gallstone disease risk.

• A standard deviation increase in Life’s Essential 8 (le8) decreases gallstone odds by 29%.
• Life’s Crucial 9 (lc9), which includes mental health, reduces odds by 31% and shows better predictive power than le8.

Consider integrating lifestyle assessments into patient evaluations to lower gallstone disease risk.

• lc9 offers a stronger framework for lifestyle counseling and prevention strategies during surgical decision-making.