Nicotine’s Toxic Impact on Chronic Wounds

Nicotine hinders healing for chronic wounds, complicating patient recovery.

Identified 160 targets linking nicotine to chronic wound failure.
Core inflammatory factors like TNF and IL-6 disrupted healing pathways.

Surgeons should consider nicotine’s role when assessing wound recovery potential in smokers.

Strong binding affinity of nicotine to key targets TNF (-5.6 kcal/mol) and IL-6 (-5.0 kcal/mol) was confirmed.

Journal Article by Guo G, Xu Y (…) Jiang Y et 2 al. in Int J Low Extrem Wounds

read the whole article in Int J Low Extrem Wounds

open it in PubMed

Summaries are written to help you decide what to read. They do not replace the full paper.

Free · 5 minutes a day

Get every new paper in Wounds.

Plus the Daily Selection: the five most relevant papers of the day, each cut to its key points.

The latest stitches

Br J Surg8 Sep 2026

Intrathecal Morphine Offers Effective Pain Control Post-Pancreatectomy

A study shows that single-shot intrathecal morphine (ITM) is non-inferior to continuous wound infiltration (CWI) for pain management after open pancreatoduodenectomy, with a significant advantage in early pain control.

JAMA Surg4 Sep 2026

Incisional Negative Pressure Wound Therapy Reduces SSIs

In a systematic review of 85 trials, incisional negative pressure wound therapy (INPWT) significantly lowered the risk of overall surgical site infections (SSIs) and related wound complications compared to standard dressings.

JAMA Surg3 Sep 2026

AI Model Accurately Detects Surgical Site Infections from Images

A deep learning model demonstrates strong potential for detecting surgical site infections (SSIs) from wound photographs, which could enhance postoperative monitoring and early diagnosis.

All papers in Wounds →