Postoperative C-reactive protein (CRP) can reduce reoperation rates by guiding safe early discharge following colectomies.

• CRP measured on day three post-surgery has a sensitivity of 77.8% and specificity of 84.0% for detecting anastomotic leakage.
• A CRP threshold of less than 15.0 mg/dl indicates a 96.1% negative predictive value for low leakage risk, enabling quicker patient discharge.

Utilizing CRP levels can help streamline patient recovery while maintaining safety in surgical practice.