Upfront pancreatectomy with venous resection shows promising outcomes in select pancreatic cancer patients.

• 30-day mortality is low at 1.2%, while 90-day mortality is 3.7%.
• Median overall survival is 19.8 months, with 1-, 2-, and 3-year survival rates of 71.4%, 40.8%, and 23.2%.
• Key predictors of decreased survival include older age (>65 years), high preoperative CA19-9, and poor tumor differentiation.

Adjuvant chemotherapy significantly enhances survival outcomes, emphasizing its role in postoperative care.