Enhancing Outcomes in High-Risk Rectal Cancer Patients

Total neoadjuvant therapy (TNT) significantly improves response and survival in high-risk rectal cancer patients.

Clinical complete response rate with TNT was 25.8%, compared to 4.0% with conventional chemoradiotherapy (p < 0.001).
TNT showed superior overall survival (hazard ratio 0.48) and disease-free survival (hazard ratio 0.62) versus chemoradiotherapy.

Adopting TNT can facilitate organ preservation strategies while maintaining or improving surgical outcomes.

Key risk factors influencing survival included MRI-defined T4 stage and extramural venous invasion.

Comparative Study by Li R, Zhao M (…) Sun Y et 9 al. in Int J Colorectal Dis

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