Optimized Preoperative Risk Stratification for Rectal Cancer

A new predictive model enhances risk stratification in rectal adenocarcinoma, shifting from subjective MRI assessments to objective measures.

Dynamic contrast-enhanced MRI washout and preoperative CEA levels independently predict 3-year disease-free survival.
The model outperformed standard MRI assessments, showing AUCs of 0.757-0.819 versus 0.600-0.672.

Identifying high-risk patients early means tailored treatments and potentially better outcomes.

T/N staging mediates some effects of CEA (17.7%) and washout (51.1%) on survival rates.

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