HPB & Spleen · 31 January 2026

Perihilar IPNB with Invasive Carcinoma: Crucial Findings

This study reveals key clinicopathologic insights into perihilar intraductal papillary neoplasms (IPNBs) and their association with invasive carcinoma, informing surgical management.

Of 27 cases, 21 had associated invasive carcinoma, highlighting the high incidence of malignancy in patients.
Median tumor size was 2.8 cm, with invasive tumor size averaging 1.2 cm.

Understanding these characteristics can improve patient selection for surgical intervention and inform prognosis discussions.

Genetic alterations linked to significant pathways could guide future targeted therapies.

Journal Article by Alkashash A, Samiei A (…) Zhang D et 4 al. in Am J Surg Pathol

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