Minimally invasive approaches in liver and pancreatic surgery show significant cost advantages.

• Laparoscopic ($77,657) and robotic ($89,713) surgeries have lower median hospital charges compared to open surgery ($111,051) (p < .001).
• In liver resections, laparoscopic surgery results in adjusted charge reductions of $23,564 overall, and $14,140 for early discharges.

Surgeons should consider minimally invasive techniques for both clinical benefits and cost-saving potential.

• Complications and late discharge are major predictors of increased costs (+$83,816 and +$82,039, respectively).