Prehospital whole-blood transfusion does not improve outcomes for major traumatic hemorrhage compared to standard blood component therapy.

• In a study of 616 patients, 48.7% in the whole-blood group and 47.7% in standard care experienced death or massive transfusion within 24 hours (p=0.84).
• Serious adverse events occurred more frequently in the standard-care group (37 vs. 31 in the whole-blood group).

Surgical teams should evaluate the use of whole blood in prehospital settings with caution, as benefits over traditional methods are not supported by this trial.