Same-day total thyroidectomy is feasible and safe for socioeconomically vulnerable patients, crucial for optimizing surgical flow.

• 51 out of 140 patients (36%) discharged on the same day; adoption rose from 32% to 88%.
• Complications were similar between same-day and overnight groups, with no hypoparathyroidism cases in same-day patients.

Surgeons can confidently implement same-day discharges to enhance efficiency without compromising patient safety.

• Median post-operative time was significantly reduced: 5.1 hours for same-day vs. 22.7 hours for overnight stays.