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Novel Radiation Approach Elevates Outcomes in Locally Advanced Pancreatic Cancer

Hypofractionated ablative radiation therapy before surgery improves overall survival in locally advanced pancreatic cancer.

  • 38% overall survival at 2 years; 54% for those who underwent resection.
  • Only 11% local progression and 73% distant metastasis rates at 2 years.

This strategy shows no increase in surgical morbidity, making it significant for patient selection and preoperative planning in LAPC.

  • 94% of participants received mFOLFIRINOX, highlighting effective induction therapy prior to radiation.

Journal Article by Reyngold M, Wei AC (…) Crane CH et 20 al. in JAMA Surg

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