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Liver Resection Improves Outcomes in Advanced Hepatocellular Carcinoma

In patients with advanced hepatocellular carcinoma who responded to systemic therapy, surgical resection significantly prolongs time to treatment failure compared to maintenance therapy.

  • Median time to treatment failure was 20.4 months with surgery versus 11.8 months with maintenance therapy (hazard ratio 0.60; p=0.015).
  • Adverse events were higher in the surgery group (39%) versus maintenance (21%), with two treatment-related deaths linked to therapy.

Consider surgical resection for selected patients post-systemic therapy to enhance treatment duration before progression.

Clinical Trial, Phase III by Sun HC, Zhu XD (…) Fan J et 22 al. in Lancet

Copyright © 2026 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.

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