Indocyanine green (ICG) fluorescence imaging enhances lesion detection during minimally invasive liver resection for colorectal liver metastases, achieving a patient-level R0 resection rate of 92.5%.

• ICG shows promise for better visualization and margin orientation, potentially improving surgical outcomes.
• Current evidence does not clearly demonstrate its advantage over conventional techniques, emphasizing the need for more rigorous randomized trials.

Surgeons should consider integrating ICG in selected cases while remaining mindful of the limited comparative data available.