Stenting as a bridge to surgery for non-metastatic obstructing left-sided colorectal cancer increases the risk of peritoneal recurrence, especially in cases of T4 tumors, diabetes, and nodal positivity. However, no significant differences were found in overall survival, cancer-specific survival, or recurrence-free survival between stenting and upfront emergency surgery. Journal Article by Lin W, Chok AY, […]
Author: STITCHES Newsletter
Comparison of Single Anastomosis Duodenal Switch and Roux-en-Y Gastric Bypass in High-BMI Patients
Patients with BMI ≥ 50 kg/m undergoing single anastomosis duodenal switch (SADI-S) had higher and sustained weight-loss results compared to Roux-en-Y gastric bypass (RYGB), along with better comorbidity resolution. Both procedures showed similar safety profiles, but further research is needed to confirm the long-term safety of SADI-S. This multicenter retrospective study included 968 patients, indicating the potential benefits […]
Underutilization of Anti-obesity Medications Post-Bariatric Surgery
After bariatric surgery, many patients experience insufficient weight loss or regain. This study examines the utilization of anti-obesity medications (AOMs) post-surgery using a large database. Among 59,160 patients, AOM use was highest for topiramate, with varying age and racial distributions. Despite weight concerns, AOMs are underused, suggesting a need to address barriers and consider AOMs […]
Upcoming Therapies Address Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a leading cause of liver transplantations in western countries, with metabolic dysfunction-associated steatohepatitis (MASH) progressing to fibrosis, cirrhosis, and liver failure. Researchers anticipate the approval of the first drug for MASH by 2024, exploring pathways like thyroid hormone receptors and peroxisome proliferator-activated receptors. Phase 3 trials focus […]
IPMN Surveillance Enhances Early PDAC Diagnosis and Outcomes
Long-term surveillance of IPMNs led to early diagnosis and better outcomes of concomitant PDAC. Patients with IPMNs had higher rates of early cancer stage identification and R0 resection compared to those without IPMNs. Concomitant PDACs were associated with longer overall survival, with a 5-year survival rate higher than non-IPMN-associated PDACs. This study highlights the importance […]
Improved Survival Outcomes with Modern Multimodality Regimens for Pancreatic Cancer
Researchers analyzed 727 pancreatic cancer patients who received neoadjuvant therapy and pancreatectomy from 1998 to 2018. They found an increase in neoadjuvant chemotherapy use and a shift in the timing of recurrence risk from postoperative year 1 to year 2. Overall survival improved over time, predominantly due to better post-recurrence survival rates. Recurrence rates remained […]
Mechanical and Oral Antibiotics Bowel Preparation (MOABP) reduces postoperative complications in elective rectal resection
Moabp significantly reduced overall postoperative complications, surgical site infections (SSIs), and anastomotic dehiscences in patients undergoing elective rectal resection compared to those receiving mechanical bowel preparation (MBP) plus a placebo. Patients in the Moabp group had lower rates of complications and SSIs, highlighting the potential of Moabp as a standard treatment in reducing morbidity after […]
Study finds payer-negotiated prices not clinically significant for surgical outcomes in common cancers
Research examined payer-negotiated prices for surgical oncology services at NCI-designated cancer centers and their impact on clinical outcomes. Prices varied greatly within and between centers, but the effect on morbidity and mortality was statistically significant, yet clinically negligible across colon, lung, and pancreas cancer cohorts. Higher prices were not linked to better clinical quality. Overall, […]
Biologic Resectability for Surgery in Oligometastatic Pancreatic Cancer
Researchers explore the concept of biologic resectability in defining patient selection for metastasectomy in oligometastatic pancreatic ductal adenocarcinoma (PDAC). They assess safety and oncologic outcomes of metastasectomy in liver, peritoneum, and lung, and evaluate biomarkers like radiographic findings, biochemical markers (CA 19-9, CEA), and inflammatory markers. The study emphasizes the importance of considering biologic, rather […]
Improved Technique for Laparoscopic Right Anterior Sectionectomy using Glissonean Approach and Indocyanine Green Fluorescence Imaging
Combining the Glissonean approach and indocyanine green fluorescence imaging aids in performing laparoscopic right anterior sectionectomy with precision, particularly in locating transection planes near the middle and right hepatic veins. In a case study, this technique enabled successful resection of a hepatocellular carcinoma with minimal blood loss and a short postoperative recovery period. Improved guidance […]