Estrogen receptor-α ablation has been shown to reverse muscle fibrosis and prevent inguinal hernias, conditions affecting about 50% of men by age 75. Using a humanized mouse model, findings reveal how esr1 drives fibroblast proliferation and extracellular matrix deposition linked to hernia formation. Furthermore, pharmacological inhibition of esr1 restored normal muscle architecture and reversed existing […]
Category: Hernia
ETEP reduces post-operative pain compared to IPOM+ in hernia repair
Enhanced total extraperitoneal repair (ETEP) was compared with intraperitoneal onlay mesh repair-plus (IPOM+) for midline ventral hernia repair in a randomized trial involving 48 patients. Results indicated that ETEP had significantly longer operative times but resulted in notably lower pain scores at 6 and 24 hours, with fewer patients requiring rescue analgesia. Complications and recurrence […]
Retrograde puncture method for trocar placement proves effective.
A retrospective analysis of 1,388 patients undergoing laparoscopic total extraperitoneal repair for groin hernias demonstrated that the retrograde puncture method for trocar placement is both feasible and safe. All surgeries were successful without conversion to open procedures. Notably, the average time for unilateral trocar placement was 6.36 minutes, and no patients experienced recurrence or severe […]
Quadratus lumborum blocks reduce postoperative opioid consumption.
A retrospective analysis of 102 patients undergoing open abdominal wall reconstruction revealed that those receiving quadratus lumborum blocks experienced minimal opioid consumption in the first 24 hours post-surgery, with a median of 8 morphine milliequivalents (MMEs). By day 2, opioid use peaked at a median of 47 MMEs before declining. Additionally, the median length of […]
Intraoperative surgeon metrics predict robotic herniorrhaphy outcomes
Machine learning analysis on robotic ventral hernia repair data revealed that intraoperative surgeon performance indicators significantly influence postoperative complications. Evaluating 520 patients, the study achieved high predictive accuracy (0.95) for complications using various algorithms. Notably, 6.3% experienced complications at discharge, emphasizing the interplay between surgical techniques and patient-specific factors. The findings pave the way for […]
Minimally invasive endoscopic onlay repair shows low complication rates
A systematic review and meta-analysis of 12 studies involving 480 patients indicated that minimally invasive endoscopic onlay repair (endor) for diastasis recti and ventral hernia is a safe technique. The intraoperative complication and conversion rates were low at 1%, with a seroma rate of 25%. Postoperative complications included a 1% rate of surgical site infections […]
Estrogen receptor alpha ablation prevents muscle fibrosis and hernias.
Ablation of estrogen receptor alpha in fibroblasts significantly inhibits lower abdominal muscle fibrosis and inguinal hernia formation, which affects half of men by age 75. Researchers utilized a humanized mouse model to demonstrate that estrogen receptor alpha drives fibroblast proliferation and extracellular matrix deposition. Pharmacological inhibition effectively reversed existing hernias while restoring normal muscle structure. […]
Emphasizing patient-reported outcomes in hernia surgery
The AFTERHERNIA Project aims to prioritize patient-reported outcomes in groin and ventral hernia repairs, moving beyond traditional focus on clinical metrics. By surveying Danish patients over a decade, the initiative collects data through specialized questionnaires, linking patient experiences with clinical outcomes and long-term complications. This approach seeks to transform current clinical guidelines and enhance patient […]
Significant research waste identified in gastroesophageal trials
Over the past 20 years, an analysis of 182 randomized controlled trials (RCTs) on gastroesophageal reflux disease and hiatal hernia highlighted that over 86.7% exhibited significant research waste. The majority of trials were drug-related, primarily conducted in North America and Asia, with deficiencies found in various aspects such as reporting adequacy and design flaws. This […]
Reduction in hernia surgery reoperations reported over 30 years
Analysis of 368,502 groin hernia surgeries in Sweden from 1992 to 2021 reveals a significant decrease in reoperation rates for recurrence, particularly among females. Advances in surgical techniques from traditional suture repairs to modern laparo-endoscopic methods have contributed to these improved outcomes. The findings demonstrate a shift in operative practices and highlight the effectiveness of […]