High baseline liver function scores predict worse long-term survival in biliary tract cancer surgery. In a study of 616 patients, high APRI+ALBI scores correlated with median overall survival of 39.8 months vs. 62.9 months for low scores. The high score group also faced more complications and a 90-day mortality rate linked to major hepatectomy and […]

Extended liver resection for locally advanced intrahepatic cholangiocarcinoma (LAICC) shows promising outcomes, challenging previous doubts about surgical futility. 90-day mortality is low at 5% with an overall morbidity of 56%. Median overall survival is 58 months; recurrence-free survival is 23 months. Nodal status is crucial for prognosis—patients with nodal involvement had significantly lower survival rates. […]

Adding indocyanine green fluorescence imaging to intraoperative ultrasound significantly improves the detection of liver cancer lesions, a crucial advancement for surgical outcomes. Sensitivity increases dramatically to 99.78% compared to just 86.8% with ultrasound alone. The combination showed a 15.07 odds ratio over ultrasound alone, indicating a substantial advantage in lesion detection. This technique could reduce […]

Robotic left-sided pancreatectomy is safe during the learning curve, challenging the notion of increased risk during early cases. Major morbidity rates were similar between competency (14.5%) and proficiency phases (14.0%), p = .981. Predictors of major morbidity included male sex, preoperative pancreatitis, and multivisceral resection. Surgeons should remain vigilant about case complexity as proficiency increases. […]

A study reveals that pancreatic ductal adenocarcinoma morphology predicts survival after surgery, impacting patient selection and prognosis. 400 patients analyzed, identifying 10 morphologic subtypes; gland-forming was most common (41.8%). Heterogeneous tumors (38.3% of cases) are linked to worse outcomes, including higher nodal metastasis and lower survival rates (median 30.1 months). Consider integrating morphologic subtype and […]

Detecting circulating tumor DNA (ctDNA) mutations in localized pancreatic cancer patients undergoing neoadjuvant chemotherapy can guide surgical decisions and predict outcomes. 49.3% of patients had mutant KRAS ctDNA at diagnosis; this rose to 69.6% after chemotherapy. Patients who cleared ctDNA during treatment had improved overall survival (18.4 months vs. not reached, p < 0.05). Identifying […]

Current study identifies radial margin distance cutoffs that significantly impact survival outcomes in perihilar cholangiocarcinoma. Radical margin distance (rmd) of 0 mm correlates with a 5-year overall survival rate of only 21.8%, while ≥1.0 mm shows 78.5% survival. Recurrence rates are starkly different: 83.5% for rmd of 0 mm versus just 23.9% for rmd ≥1.0 […]