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Quantifying methylated circulating tumor DNA effectively monitors HCC burden without the need for biopsy. Tumor methylation scores rapidly decline postoperatively in surgical HCC patients. Preoperative tms moderately correlates with tumor burden on pathology. Δtms is better associated with tumor progression than Δalpha-fetoprotein, and a composite…
Intravenous administration of an oncolytic virus (cf33) engineered to express a nonsignaling CD19 antigen (CD19t) effectively infected and expressed CD19t in pancreatic tumors, triggering cell killing and increased immunogenic response by CD19-CAR T cells. Combination therapy of virus+CAR T cells led to significant tumor regression…
Analysis of 125 patients with molecular profiling for intrahepatic cholangiocarcinoma revealed actionable molecular alterations in 45%, leading to targeted therapies in 21 patients. Patients with such alterations had significantly improved overall survival, with mean survival of 34.1 vs 23.6 months in those with actionable alterations.…
Left-sided liver resection for perihilar cholangiocarcinoma is associated with lower 90-day mortality and superior overall survival compared to right-sided resection. In a study of 1701 patients, 90-day mortality rates were 9% for left-sided and 18% for right-sided resection, with median overall survival of 30 months…
DNA methylation profiling accurately classifies nonductal primary pancreatic neoplasms, with a random forest model achieving 96.9% accuracy and near perfect precision in identifying nonpancreatic neoplasms. Methylation signatures offer a valuable diagnostic tool with minimal misdiagnosis risk, even in preoperative settings.
Patients with resectable pancreatic cancer were randomized to receive either adjuvant gemcitabine or perioperative FOLFIRINOX. Perioperative FOLFIRINOX led to almost doubled median progression-free survival compared to adjuvant gemcitabine in patients who underwent surgical resection. Despite premature trial termination due to poor accrual, perioperative FOLFIRINOX showed…
One in ten patients with pancreatic ductal adenocarcinoma experiences very early recurrence after surgery (classified as biological R2), necessitating routine imaging within 12 weeks. Body-tail site lesion was the only preoperative predictor, with higher pt, g3 differentiation, and high lymph node ratio as pathological predictors.…
Textbook outcome (TO) was achieved in one-third of patients after pancreatoduodenectomy (PD) for nonfunctioning pancreatic neuroendocrine tumors (NF-PANNETs). Tumor size, minimally invasive approach, and surgical volume were predictors of TO. TO was not associated with improved long-term survival, with similar rates seen in patients with…
Researchers developed and validated a novel Difficulty Score System for robotic hepatectomy based on 274 patients. Factors such as neoadjuvant chemotherapy, tumor characteristics, extent of resection, and additional procedures were associated with operative time and blood loss, resulting in difficulty scores ranging from 1 to…
Characterization of the tumor microbiome in intrahepatic cholangiocarcinoma revealed a higher diversity than in adjacent nontumoral liver tissues, with increased abundance of specific bacterial groups. Higher tumor microbial diversity was linked to lymph node metastasis and predicted shorter overall and recurrence-free survival. A risk score…
