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In patients with resectable pancreatic adenocarcinoma, a study analyzed body composition metrics from baseline CT scans in the SWOG S1505 trial. Visceral adipose tissue (VATA) was associated with overall survival, but no significant links were found between survival and sarcopenia or sarcopenic obesity. This prospective…
Researchers analyzed data from 230 patients with solitary liver metastases from colorectal cancer undergoing liver resection. They found that initial N2 stage, hypoalbuminemia before surgery, and high neutrophil-to-lymphocyte ratio after surgery were independent prognostic factors for recurrence-free and overall survival. Patients with these factors should…
Perioperative blood transfusion during curative hepatectomy for hepatocellular carcinoma was associated with a higher incidence of postoperative complications and longer hospitalization, but did not significantly impact overall survival. A total of 846 patients were studied, with 125 receiving transfusions and 720 not. Patients who received…
Multibipolar radiofrequency ablation (RFA) resulted in lower local recurrence rates in patients with intrahepatic cholangiocarcinoma (ICCA) compared to monopolar RFA. Treatment-naive patients had a median overall survival of 26 months and tumor size and Child-Pugh B score were associated with higher mortality. Distant recurrence rates…
Surgeons' classification of pancreatic ductal adenocarcinoma (PDAC) resectability varies significantly, regardless of the adopted classification system, according to a survey distributed to international HPB surgeons. The study found notable discordance among surgeons in determining resectability, with a median concordance rate of 62.5% with their chosen…
Researchers developed a preoperative risk score based on early recurrence to estimate outcomes after liver resection in non-cirrhotic hepatocellular carcinoma patients. By analyzing data from 263 patients, they identified macroscopic vascular invasion, multifocal tumor, and spontaneous tumor rupture as predictors of early recurrence. This score…
Researchers investigated perioperative factors influencing survival in pancreatic ductal adenocarcinoma (PDAC) surgery. Analyzing a Danish cohort (2011–2020), they found that perioperative blood transfusions were linked to significantly shorter overall survival (OS) in resected PDAC patients (HR 2.53, p = 0.005), with a marked difference at 72 months…
Researchers analysed 338 cyst fluid samples from 190 IPMN patients and found no significant difference in microbiome signatures compared to negative controls. In patients who recently had invasive procedures, a gut-associated microbe outlier signal was evident. The study concluded that IPMNs and pancreatic cystic neoplasms…
Complete liver splitting along the demarcation line induced higher portal vein pressure and more rapid future liver remnant hypertrophy than partial or ectopic liver splitting after portal vein ligation in a rat model. The portal hemodynamic alterations, rather than inflammatory cytokine release, played a significant…
Preoperative biliary obstruction and operation time were identified as significant risk factors for postoperative infection in choledochoscopy for intrahepatic bile duct stones. Biliary tract infections, particularly with Escherichia coli, were the main cause of postoperative infection. Biliary tract obstruction and body mass index were independent…
