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Elevated postoperative serum AST and ALT levels, measured as changes from preoperative values, were associated with increased postoperative morbidity in hepatocellular carcinoma patients undergoing curative resection. The optimal cutoff value for postoperative complications was identified as AST/ALT change ≥5. Routine use of AST and ALT…
Patients with early-onset intrahepatic cholangiocarcinoma (ICC) had worse 5-year recurrence-free and disease-specific survival compared to patients with typical-onset ICC. Genomic analysis revealed distinct upregulated and downregulated genes in early-onset ICC. Morphologic and clinicopathologic characteristics could not fully explain the outcome differences between the two groups,…
Gallbladder neuroendocrine neoplasms (GB NENs) are predominantly represented by neuroendocrine carcinomas. Outcomes analysis of 147 patients revealed a median overall survival (OS) of 6.14 months, with significant improvement to 20.20 months for those who received multimodality treatment versus 4.00 months for those who did not.…
The study compared endoscopic and surgical treatment in acute necrotizing pancreatitis, showing that endoscopic treatment resulted in lower peri-interventional morbidity, shorter hospital stays, and lower mortality rates. Endoscopic treatment also led to better long-term outcomes with reduced renal insufficiency, ventilation dependency, and recurrence rates, along…
Centers with liver transplant programs in France perform more difficult laparoscopic liver resections for hepatocellular carcinoma in cirrhotic patients compared to centers without transplant programs. Despite this complexity, both types of centers showed comparable safety and quality of care in terms of postoperative severe morbidity…
Repeat resection for recurrent intrahepatic cholangiocarcinoma in select patients can lead to improved survival compared to locoregional or palliative therapy alone. A 3-year post-recurrence survival rate of 47% was observed in surgically treated patients. Independent predictors of post-recurrence death included time to recurrence, site of…
Researchers successfully treated persistent biliary fistulas post-liver hydatid cyst surgeries in 14 patients using a noninvasive drain clamping technique. All fistulas closed within 8-20 days without complications. This novel approach eliminated the need for surgical reoperation and resulted in complete recovery in patients, providing a…
Portal vein stenting in peri-hilar cholangiocarcinoma patients led to 100% technical success, improvement in 75% of clinical symptoms, and enabled anticancer therapy in 69% of cases. Complications occurred in 13%, including biliary injury and cholangitis, but patency was high at 86% after one year. Stent…
Results of an international survey show substantial variability in European hpb surgery fellowship programs, highlighting the need for a more standardized clinical curriculum. Fellowships typically last one or two years, with funding provided in 70% of cases. Fellows commonly perform pancreatic and liver resections as…
Among 950 patients with pathologic T1B gallbladder cancer, receiving either simple or radical cholecystectomy, there was no significant difference in median overall survival between the two groups. This suggests that highly selected patients may not benefit from extended resection, highlighting comparable outcomes with simple cholecystectomy…
