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The first 3 years of the E-MIPS registry revealed acceptable morbidity and mortality rates after minimally invasive pancreatoduodenectomy (MIPD) in Europe. The study included 1,336 patients who underwent MIPD, with 835 robot-assisted and 501 laparoscopic procedures. The rate of centers performing laparoscopic MIPD decreased from…
A retrospective analysis compared short-term and long-term outcomes of robotic enucleation (ren) versus open enucleation (oen) for tumors in the pancreatic head and uncinate process. Of the 146 patients, 92 underwent ren with superior results in terms of shorter operative time, decreased blood loss, and…
A systematic review and spline regression analysis of 33 cohort studies involving 198,377 patients were conducted to determine the minimum volume threshold required for a specialist pancreas service to achieve optimal outcomes. The results showed that 55 pancreaticoduodenectomies (PDs) per year were needed to achieve…
In a prospective study, researchers evaluated the prognostic value of circulating tumor DNA (ctDNA) using next-generation sequencing (NGS) in patients with localized pancreatic cancer (PDAC) undergoing neoadjuvant chemotherapy (NAC). They found that ctDNA detection was associated with higher CA19-9 levels and predicted worse progression-free survival.…
Patients with resectable biliary tract cancer (BTC) who had negative peritoneal washing cytology (PWC) exhibited longer recurrence-free survival and overall survival compared to those with positive PWC. Among the analyzed patients, ampullary carcinoma showed uniformly negative PWC. Serum carbohydrate antigen 19-9 level over 80 u/ml…
Laparoscopic partial splenectomy in distal pancreatectomy may preserve splenic function and help retain immunocompetence, according to a study involving five patients. The procedure, which involves resection of the distal pancreas and the inferior portion of the spleen, was completed laparoscopically within four hours. All patients…
The study analyzed the implications of the geometric location (fundal end vs cystic ductal end) of gallbladder cancer on postoperative outcomes. Researchers compared the oncologic outcomes of 575 patients with gallbladder cancer and found that patients with cancer located on the cystic ductal end had…
Studies comparing organ-preserving pancreatectomy procedures have shown that central pancreatectomy (CP) leads to a lower incidence of new-onset or exacerbated diabetes compared to distal pancreatectomy (DP). However, CP is associated with increased morbidities such as pancreatic fistula. Spleen-preserving DP using the Kimura procedure reduces the…
Distinct intra-tumoral cell neighborhoods were identified in pancreatic ductal adenocarcinoma (PDA), with variations in immune and tumor cell subsets based on neighboring cells. Tumors from long-term survivors had a higher presence of stromal-associated macrophages, while short-term survivors had more immune-excluded tumor cells. Chemotherapy-treated tumors showed…
A multicenter study developed and validated the prealbumin-bilirubin (preALBI) score as an alternative to the widely used albumin-bilirubin (ALBI) score for predicting long-term survival after hepatectomy for hepatocellular carcinoma (HCC). The preALBI score, incorporating serum prealbumin and bilirubin levels, showed superior performance in predicting survival…
