Patients with biological borderline resectable pancreatic cancer and CA19-9 levels ≥500 u/ml show worse outcomes and need tailored surgical approaches. Cancer-specific survival is significantly lower in patients with CA19-9 ≥500 u/ml compared to those with levels <37 u/ml (p = 0.03). Higher CA19-9 is linked to increased genomic mutations, with tumors showing ≥3 driver gene […]

Postpancreatectomy acute pancreatitis (PPAP) is a key factor increasing mortality after pancreatoduodenectomy. 24.3% of patients developed clinically relevant postoperative pancreatic fistula (CR-POP), with 90-day mortality at 9% in this group. PPAP is the strongest predictor of CR-POP (odds ratio 11.76) and 90-day mortality (odds ratio 4.88). Understanding these links can help refine patient selection and […]

Young patients with intraductal papillary mucinous neoplasms (IPMNs) show excellent long-term quality of life after pancreatic surgery, informing surgical decision-making. 63% needed pancreatic enzyme replacement; 16% developed insulin-dependent diabetes. Quality of life scores (global health 71.1%, functioning 82.9%) were similar to age-matched peers. Parenchyma-sparing resections yielded particularly favorable outcomes, boosting confidence in surgical options for […]

Significant intra-pancreatic fat deposition is a crucial marker for worse survival in high-grade pancreatic neuroendocrine neoplasms. 27.6% of 87 patients had significant intra-pancreatic fat deposition (ipfd). Patients with ipfd showed a higher likelihood of tumors in the pancreatic head (75% vs. 49.2%, p = 0.030) and metabolic dysfunction-associated liver disease (20.8% vs. 3.2%, p = […]

Hepatic vein occlusion with portal vein embolization significantly boosts future liver remnant growth in 2-stage hepatectomies, impacting patient selection and stage feasibility. Hepatic vein occlusion combined with portal vein embolization led to a 36.8% increase in future liver remnant, 24.5% higher than portal vein embolization alone (p < .01). Associating liver partition and portal vein […]

Surgical resection significantly increases cure probabilities for pancreatic ductal adenocarcinoma. Cure probability for patients undergoing resection is 25.24%, compared to 6.82% for those who do not. Neoadjuvant chemotherapy before surgery improves cure rates (30.0% vs 17.05% with upfront surgery). Earlier detection and combined treatment strategies are crucial for improving long-term outcomes. Cure probabilities decrease with […]

Surgically resected early-onset pancreatic cancer shows worse outcomes and aggressive molecular features compared to late-onset cases. Patients under 50 had a median disease-free survival of 10.9 months versus 14.2 months for those 50 and older (p = 0.011). More young patients received adjuvant chemotherapy, yet their disease-free survival was shorter at 12.6 months vs. 16.0 […]

Pancreaticoduodenectomy is feasible in patients with complete situs inversus, ensuring oncologic principles are upheld. Complete R0 resection achieved in a 68-year-old with pancreatic adenocarcinoma. Complicated course included grade II adverse events with a 16-day hospital stay. Surgeons should prioritize meticulous preoperative planning and adapt intraoperatively to unique anatomical variations. Final pathology revealed high-stage disease with […]

Early protocol CT scans in high-risk patients after pancreatoduodenectomy increase detection of complications but don’t improve overall outcomes. In a prospective cohort, 76.7% of asymptomatic patients received CT scans by day 4 versus day 8 in historical controls. Abnormal findings were noted in 73.9% of scans, leading to timely intervention in 6 patients. Despite increased […]