A consensus guideline developed by the AHPBA highlights the significant role of surgical management in colorectal liver metastases (CRLM), emphasizing early surgical involvement for improved patient survival. It outlines the effectiveness and limitations of diagnostic tools, including imaging and next-generation sequencing. The guidelines advocate for treatment sequencing, combining surgical and non-surgical approaches, especially in cases […]

A new predictive model effectively identifies patients with hepatocellular carcinoma (HCC) at risk of undergoing futile upfront liver resection (LR). Among 1,633 patients analyzed, 16.2% experienced futility—defined as death or recurrence within six months. Key risk factors included tumor burden score, alpha-fetoprotein levels, and albumin-bilirubin grade. The model, which categorizes patients into risk groups, is […]

A systematic review and meta-analysis involving 2,338 participants found that arterial compression hemostasis devices significantly reduced compression hemostasis time by 13.9 minutes and limb immobilization time by 8.79 minutes compared to traditional methods. Additionally, these devices lowered the rates of local bleeding, hematoma formation, skin ecchymosis, and other vascular complications. The findings support the superiority […]

A study involving 134 patients from the RECOPANC trial found that AI-assisted analysis of pancreatic tissue composition can reliably predict postoperative pancreatic fistula (POPF) risk. The strongest determinant identified was the relative fibrotic tissue area, which outperformed conventional surgical assessments of pancreatic texture. These findings highlight the potential of digital pathology to improve risk stratification […]

Non-hepatectomy opioid reduction efforts significantly decreased opioid prescriptions after hepatectomy. An analysis of 2,005 patients revealed over 50% reductions in both intraoperative and inpatient median oral morphine equivalents, alongside a 73% decline in discharge opioids. Clinically, pain scores remained low, showing no compromise in patient comfort. Additionally, the percentage of patients discharged without opioids rose […]

A case study demonstrated the effectiveness of a multidisciplinary approach in managing perihilar cholangiocarcinoma, involving neoadjuvant therapy and interventional radiology. Neoadjuvant chemotherapy significantly reduced the tumor size, facilitating an r0 surgical resection. Additionally, interventional radiology played a critical role in addressing postoperative complications, including a life-threatening pulmonary embolism, through techniques like percutaneous pharmaco-mechanical thrombectomy. This […]

Hepatectomy guided by indocyanine green fluorescence navigation has demonstrated significant benefits over conventional methods for treating hepatocellular carcinoma. Key findings reveal reduced operation time, intraoperative blood loss, and lower transfusion rates, while improving the R0 resection rate and decreasing postoperative complications. Notably, the length of hospital stay showed no significant differences. These results suggest that […]

In biliary tract cancers (BTCs), genomic analysis revealed distinct variations in mutations across cancer subtypes based on anatomic and geographic factors. Notably, intrahepatic cholangiocarcinoma samples showed prevalent alterations in IDH1 and FGFR2, while gallbladder cancers frequently displayed TP53, ERBB2, and SMAD4 mutations. Co-mutations were ubiquitous, with significant correlations between certain co-alterations and poorer overall survival. […]