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A study developed predictive models to aid surgical decision-making for hepatic cystic echinococcosis (CE). Analyzing data from 406 patients, the Cox regression model achieved a concordance index of 0.94 and AUC of 0.96. The decision tree model highlighted imaging findings, cyst stage, and symptoms as…
Researchers developed three nomograms to predict short-term and long-term outcomes in patients with large hepatocellular carcinoma (HCC) post-liver resection. These models demonstrated good predictive performances with c-indices of 0.764 for surgical risk, 0.709 for overall survival (OS), and 0.695 for recurrence-free survival (RFS) in validation…
A machine learning model using extreme gradient boosting (XGBoost) was developed to predict bile leaks after hepatectomy for liver cancer. The model analyzed data from over 22,000 patients, achieving areas under receiver operating characteristic curves (AUROC) of 0.748, 0.719, and 0.711 in various patient cohorts.…
Immune checkpoint inhibitors are reshaping treatment for advanced hepatocellular carcinoma, establishing new standards and encouraging further research. A combination of atezolizumab and bevacizumab shows high response rates, prompting investigations into their roles in peri-operative settings and liver transplantation. However, there are concerns regarding immunosuppression and…
Changes in perioperative serum transaminase levels, specifically aspartate and alanine aminotransferase, were found to predict long-term survival following liver resection for hepatocellular carcinoma. A murine model demonstrated that hepatic ischemia/reperfusion injury led to increased tumor recurrence. Analyzing the ratio of aspartate to alanine aminotransferase on…
Laparoscopic radical antegrade modular pancreatosplenectomy, when combined with portal vein reconstruction and celiac axis resection, demonstrated safety and efficacy for treating pancreatic neck-body cancer. A 74-year-old patient underwent the procedure following neoadjuvant chemotherapy, resulting in significant tumor size reduction. The surgery lasted 300 minutes with…
A dorsal approach to the middle hepatic vein from the hilar plate in laparoscopic hemihepatectomy has shown promising results. In a study involving 28 patients, the average surgery duration was 260 minutes, with median blood loss at 80 ml. Postoperative major complications occurred in only…
A comparative analysis of surgical approaches for extrahepatic cholangiocarcinoma revealed that hemihepatectomy (HH) had fewer severe complications, lower pancreatic fistula rates, and shorter hospital stays than pancreatoduodenectomy (PD). However, HH showed a higher perioperative mortality rate among right hemihepatectomy patients. At one year post-surgery, patients…
A multicenter study found that 3.3% of 4621 hepatocellular carcinoma patients developed intrahepatic and perihepatic abscesses (ipha) post-hepatectomy. These abscesses led to longer hospital stays (16 vs. 11 days), increased 30-day readmission rates (33% vs. 3.1%), and higher 90-day mortality (11.7% vs. 2.8%). Key risk…
A network meta-analysis of seven randomized controlled trials involving 1,336 patients revealed that laparoscopic pancreatoduodenectomy (LPD) offers shorter hospital stays and reduced intraoperative blood loss compared to open pancreatoduodenectomy (OPD). However, LPD was associated with longer operative durations. In contrast, robotic pancreatoduodenectomy (RPD) showed no…
